Evidence for parasympathetic innervation of white adipose tissue, clearing up some vagaries.
نویسندگان
چکیده
Felix Kreier and Ruud M. Buijs Netherlands Institute for Neuroscience, Amsterdam; Department of Endocrinology and Metabolism, Academic Medical Center of the University of Amsterdam, Amsterdam; Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands; and Instituto de Investigaciones Biomedicas Universidad National Aútonoma de Mexico, Mexico City, Mexico
منابع مشابه
Dual innervation of white adipose tissue: some evidence for parasympathetic nervous system involvement.
The regulation of total body fat was first formally suggested in the lipostatic theory of Kennedy (1), and since that time, the mechanisms underlying the control of lipid energy stores have been sought. The waxing and waning of circulating factors that promote lipid storage or mobilization (e.g., insulin and adrenal medullary catecholamines, respectively) may be the method by which the brain ad...
متن کاملThematic review series: adipocyte biology. Sympathetic and sensory innervation of white adipose tissue.
During our study of the reversal of seasonal obesity in Siberian hamsters, we found an interaction between receptors for the pineal hormone melatonin and the sympathetic nervous system (SNS) outflow from brain to white adipose tissue (WAT). This ultimately led us and others to conclude that the SNS innervation of WAT is the primary initiator of lipid mobilization in these as well as other anima...
متن کاملWhite adipose tissue lacks significant vagal innervation and immunohistochemical evidence of parasympathetic innervation.
Converging evidence indicates that white adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS) based on immunohistochemical labeling of a SNS marker (tyrosine hydroxylase [TH]), tract tracing of WAT sympathetic postganglionic innervation, pseudorabies virus (PRV) transneuronal labeling of WAT SNS outflow neurons, and functional evidence from denervation studies. Recently, W...
متن کاملSCN efferents to peripheral tissues: implications for biological rhythms.
The suprachiasmatic nucleus (SCN) is the principal generator of circadian rhythms and is part of an entrainment system that synchronizes the animal with its environment. Here, we review the possible communication of timing information from the SCN to peripheral tissues involved in regulating fundamental physiological functions as revealed using a viral, transneuronal tract tracer, the pseudorab...
متن کاملVagaries of adipose tissue innervation.
ADIPOSE TISSUE DOES NOT SEEM to be innervated in any significant manner by the vagus nerve after all. As reported by Giordano et al. (9) in this issue, retrograde tracing with pseudorabies virus from at least one fat pad in the Siberian hamster reveals only the occasional neuron in the vagal motor nucleus and nerve fibers in adipose tissue of mouse, rat, and hamster do not exhibit any of the ma...
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ورودعنوان ژورنال:
- American journal of physiology. Regulatory, integrative and comparative physiology
دوره 293 1 شماره
صفحات -
تاریخ انتشار 2007